EPUB and E available Open Access under CC-BY-NC-ND licence. We tend to hold people responsible for their choices, but not for what they can’t control: their nature, genes or biological makeup.This thought-provoking collection redefines the boundaries of moral responsibility.It shows how epigenetics reveals connections between our genetic make-up and our environment.The essays challenge established notions of human nature and the nature/nurture divide and suggest a shift in focus from individual to collective responsibility.Uncovering the links between our genetic makeup, environment and experiences, this is an important contribution to ongoing debates on ethics, genetics and responsibility.