Viral Proteases, Volume 58 in The Enzymes series, presents a comprehensive overview of recent advances in the structural and functional understanding of viral proteases and their potential as drug targets.This new volume includes chapters covering a wide range of topics, including Viral proteases as targets for antiviral drugs, Structural biology of viral proteases, Computational approaches for designing viral protease inhibitors, The peptidomimetic approach for the design of viral protease inhibitors, HIV protease and its inhibition, and much more. Additional sections cover Hepatitis C virus (HCV) proteases: structure, function and inhibition strategies, Coronaviruses main proteases and their inhibitors, Coronaviruses papain-like proteases, Flaviviruses proteases (Zika, West Nile, Dengue), Bacteriophage endolysins, and Challenges for developing selective viral protease inhibitors as anti-infectives.