In this issue, guest editors bring their considerable expertise to this important topic. Contains 42 patient scenarios including a patient with a pacemaker, history of stroke, and stent placement presenting for extraction of the lower molar; a patient with a history of COPD, ischemic heart disease, and cardiac arrhythmia presenting for restorative treatment; an adolescent with poorly managed asthma referred for pulp therapy in a permanent tooth; a patient with severe dental anxiety and episodes of fainting in need of dental restoration; and more. Provides in-depth clinical reviews on clinical decisions in medically complex dental patients, offering actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field.Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.